Color discrimination deficits in Parkinson's disease are related to cognitive impairment and white‐matter alterations
Identifieur interne : 001454 ( Main/Exploration ); précédent : 001453; suivant : 001455Color discrimination deficits in Parkinson's disease are related to cognitive impairment and white‐matter alterations
Auteurs : Josie-Anne Bertrand [Canada] ; Christophe Bedetti [Canada] ; Ronald B. Postuma [Canada] ; Oury Monchi [Canada] ; Daphné Génier Marchand [Canada] ; Thomas Jubault [Canada] ; Jean-François Gagnon [Canada]Source :
- Movement Disorders [ 0885-3185 ] ; 2012-12.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Cognitive disorder, Color, Color Perception (physiology), Color Vision Defects (etiology), Color Vision Defects (physiopathology), Diffusion tensor imaging, Discrimination, Female, Humans, Magnetic Resonance Imaging (methods), Male, Middle Aged, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson disease, Parkinson's disease, White matter, color discrimination deficit, diffusion tensor imaging, mild cognitive impairment.
- MESH :
- complications : Parkinson Disease.
- etiology : Color Vision Defects.
- methods : Magnetic Resonance Imaging.
- pathology : Parkinson Disease.
- physiology : Color Perception.
- physiopathology : Color Vision Defects, Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Color discrimination deficit is a common nonmotor manifestation of Parkinson's disease (PD). However, the pathophysiology of this dysfunction remains poorly understood. Although retinal structure changes found in PD have been suggested to cause color discrimination deficits, the impact of cognitive impairment and cortical alterations remains to be determined. We investigated the contribution of cognitive impairment to color discrimination deficits in PD and correlated them with cortical anomalies. Sixty‐six PD patients without dementia and 20 healthy controls performed the Farnsworth–Munsell 100 hue test and underwent a comprehensive neuropsychological assessment for mild cognitive impairment diagnosis. In a subgroup of 26 PD patients, we also used high‐definition neuroanatomical magnetic resonance imaging for cortical thickness and diffusion tensor analysis. PD patients with mild cognitive impairment performed poorly on the Farnsworth–Munsell 100 hue test compared with PD patients without mild cognitive impairment and controls. In PD patients, performance on the Farnsworth–Munsell 100 hue test was correlated with measures of visuospatial abilities and executive functions. Neuroimaging analysis revealed higher mean and radial diffusivity values in right posterior white‐matter structures that correlated with poor performance on the Farnsworth–Munsell 100 hue test. No cortical thickness correlation reached significance. This study showed that cognitive impairment makes a major contribution to the color discrimination deficits reported in PD. Thus, performance on the Farnsworth–Munsell 100 hue test may reflect cognitive impairment more than color discrimination deficits in PD. Poor performance on the Farnsworth–Munsell 100 hue test was also associated with white‐matter alterations in right posterior brain regions. © 2012 Movement Disorder Society
Url:
DOI: 10.1002/mds.25272
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-12">2012-12</date><biblScope unit="volume">27</biblScope><biblScope unit="issue">14</biblScope><biblScope unit="page" from="1781">1781</biblScope><biblScope unit="page" to="1788">1788</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">E96BF1D8C57CEA2277B72F45DB58349935E2C233</idno><idno type="DOI">10.1002/mds.25272</idno><idno type="ArticleID">MDS25272</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cognitive disorder</term><term>Color</term><term>Color Perception (physiology)</term><term>Color Vision Defects (etiology)</term><term>Color Vision Defects (physiopathology)</term><term>Diffusion tensor imaging</term><term>Discrimination</term><term>Female</term><term>Humans</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Nervous system diseases</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>White matter</term><term>color discrimination deficit</term><term>diffusion tensor imaging</term><term>mild cognitive impairment</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Color Vision Defects</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Color Perception</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Color Vision Defects</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Couleur</term><term>Discrimination</term><term>Déficit cognitif léger</term><term>Imagerie du tenseur de diffusion</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Substance blanche</term><term>Trouble cognitif</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Color discrimination deficit is a common nonmotor manifestation of Parkinson's disease (PD). However, the pathophysiology of this dysfunction remains poorly understood. Although retinal structure changes found in PD have been suggested to cause color discrimination deficits, the impact of cognitive impairment and cortical alterations remains to be determined. We investigated the contribution of cognitive impairment to color discrimination deficits in PD and correlated them with cortical anomalies. Sixty‐six PD patients without dementia and 20 healthy controls performed the Farnsworth–Munsell 100 hue test and underwent a comprehensive neuropsychological assessment for mild cognitive impairment diagnosis. In a subgroup of 26 PD patients, we also used high‐definition neuroanatomical magnetic resonance imaging for cortical thickness and diffusion tensor analysis. PD patients with mild cognitive impairment performed poorly on the Farnsworth–Munsell 100 hue test compared with PD patients without mild cognitive impairment and controls. In PD patients, performance on the Farnsworth–Munsell 100 hue test was correlated with measures of visuospatial abilities and executive functions. Neuroimaging analysis revealed higher mean and radial diffusivity values in right posterior white‐matter structures that correlated with poor performance on the Farnsworth–Munsell 100 hue test. No cortical thickness correlation reached significance. This study showed that cognitive impairment makes a major contribution to the color discrimination deficits reported in PD. Thus, performance on the Farnsworth–Munsell 100 hue test may reflect cognitive impairment more than color discrimination deficits in PD. Poor performance on the Farnsworth–Munsell 100 hue test was also associated with white‐matter alterations in right posterior brain regions. © 2012 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Bertrand, Josie Nne" sort="Bertrand, Josie Nne" uniqKey="Bertrand J" first="Josie-Anne" last="Bertrand">Josie-Anne Bertrand</name></noRegion><name sortKey="Bedetti, Christophe" sort="Bedetti, Christophe" uniqKey="Bedetti C" first="Christophe" last="Bedetti">Christophe Bedetti</name><name sortKey="Bedetti, Christophe" sort="Bedetti, Christophe" uniqKey="Bedetti C" first="Christophe" last="Bedetti">Christophe Bedetti</name><name sortKey="Bertrand, Josie Nne" sort="Bertrand, Josie Nne" uniqKey="Bertrand J" first="Josie-Anne" last="Bertrand">Josie-Anne Bertrand</name><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Gagnon, Jean Rancois" sort="Gagnon, Jean Rancois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Genier Marchand, Daphne" sort="Genier Marchand, Daphne" uniqKey="Genier Marchand D" first="Daphné" last="Génier Marchand">Daphné Génier Marchand</name><name sortKey="Genier Marchand, Daphne" sort="Genier Marchand, Daphne" uniqKey="Genier Marchand D" first="Daphné" last="Génier Marchand">Daphné Génier Marchand</name><name sortKey="Jubault, Thomas" sort="Jubault, Thomas" uniqKey="Jubault T" first="Thomas" last="Jubault">Thomas Jubault</name><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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